Chanca Piedra (Stonebreaker)
Chemotherapy used today often induces apoptosis in tumor cells, but this therapy usually does not work after tumors have metastasized. There is a poor prognosis from that point. A study at Department of Medical Microbiology, Malaysia was done of the antimetastatic capacity of Phyllanthus plant species against breast and lung tumor cells. Phyllanthus niruri was shown to work against hepatitis B virus and may also, effective against prostate tumors and malignant melanoma. The Phyllanthus extracts reduced the invasion, migration and adhesion functions of the tumors, which impair the ability of tumors to spread. The plant extracts had low toxicity toward normal cells. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/21698198
(Tabebuia impetiginosa). Taheebo, extracted from the inner bark of the Pau D'arco tree found in the Brazilian Amazon, exhibits selective anti-proliferative effects in carcinoma cell lines. A study identified the mechanistic leads for the inhibitory effects of Taheebo. The anti-proliferative effects of Taheebo correlate with down-regulated cell cycle regulatory and estrogen responsive genes, and up-regulated apoptosis specific and xeno-biotic metabolism specific genes. This data validate a rapid mechanistic approach to prioritise efficacious herbal medicines, thereby complementing the existing endocrine therapy for breast tumors. Pau d’Arco also contains a compound that has anti-fungal, anti-parasitic and antiviral benefits. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/19578798
(Artemesia Annua)In a new study, researchers report that artemesinin--a derivative of the wormwood plant--kills iron-enriched breast tumor cells but doesn't harm many healthy ones. Artemesinin's destructive properties are triggered by higher than normal levels of iron in tumor cells. Many experiments have found that artemesinin turns deadly in the presence of iron. Tumor cells often soak up the iron to facilitate cell division. It is postulated that iron-activated artemisinin releases highly alkylating carbon-centered radicals and ROS. ROS generation may contribute to the selective action of artemisinin on cancer cells by DNA damage, enhanced apoptosis, growth arrest and reducing angiogenesis. Clinical Study:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389338/
Curcumin is from the Turmeric plant (Curcuma longa) from the Zingiberaceae family. This plant usually requires humid and rainy environment. The main habitat of turmeric is hot areas of Asia such as India, southern China, Africa and South America. The study of cytotoxic properties of turmeric on liver cancer cells (Hep-2) showed that Curcumin plays a significant role in the prevention and treatment of primary ovarian cancer, and multiple clinical studies have proven its effectiveness. The potential of curcumin against tumors, including leukemia, lymphoma, digestive, urinary, reproductive, breast, uterus, ovary, lung, melanoma, colon cancers, and brain tumors have been shown. Apoptosis occurs due to release of cytochrome and its effect on P53 protein as well as the effect on intracellular signals is responsible for stopping cell growth.90 In fact, the mechanisms by which curcumin inhibits tumor formation are combination of properties including antioxidant, anti-inflammatory, anti-angiogenic, anti-metastatic, inhibition of cell cycle, and proapoptotic, which induce inhibitory effects on the cancer through regulating genes and molecules involved in these paths. Clinical Study:https://journals.sagepub.com/doi/full/10.1177/2156587217696927
(Uncaria tormentosa) Cat’s Claw, is a woody vine. The inner bark is a popular remedy for the treatment of inflammation, but it also enjoys a secure place as a tumor fighter. Widely employed by natives, Cat’s Claw contains a group of documented anti-cancer agents known as oxindole alkaloids. In fact, an extract of Cat’s Claw is approved in Austria as an adjunct therapy for reproductive tumors – most with notably breast tumors. Oxindole alkaloids in Cat’s Claw appear to fight the growth of breast tumor cells by inhibiting the binding of estrogen to those cells. They also help to prevent cell mutation and assist in the repair of cellular DNA. Furthermore, when used with other anti-tumor drugs, extracts of Cat’s Claw help to reduce nausea, hair loss, weight loss and other problems associated with treatment. As with soursop, many people use Cat’s Claw on their own, as part of a holistic approach to tumor treatment and as a replacement for the drug Tamoxifen. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/27180878
Graviola / Soursop
(Annona muricata) Graviola leaf extracts contain compounds that are particularly effective against tumor cells. In a 2019 study at Faculty of Veterinary Medicine in Egypt , graviola ameliorated the carcinogenic effects on antioxidant enzymatic activities and tumor marker CA 15-3. The study concluded that graviola ameliorated breast tumors potentially through upregulating apoptotic genes, downregulating the ER-α gene, increasing antioxidants, and decreasing lipid peroxidation levels. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/30151067
Anamu (Guinea Hen Weed)
(Phyllanthus niruri) Anamu is a plant used in herbal medicine. Also known as Petiveria alliacea, it's long been used in certain systems of folk medicine to strengthen the immune system and fend off sickness. Anamu was found to induce G2 cell cycle arrest and cause apoptotic cell death in a mitochondria independent way. In addition, it has been found to down regulate cytoskeleton, chaperone, signal transduction proteins, and proteins involved in metabolic pathways. Petiveria alliacea exerts multiple biological activities in vitro consistent with cytotoxicity and appears to be a good candidate to be used as an antitumor agent. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/19017389
(Urtica dioica) Artemisinins tagged with iron-carrying compounds show greater activity compared with that of artemisinin alone and triggers artemisinin cytotoxicity,with an increase in artemisinin activity up to 100-fold in some cell . Nettle is both antitumous and an iron donor which provides support for Artemesia annua. Studies have shown cell proliferation inhibitory effect of Urtica dioica on prostate cancer cells by aqueous and ethanol extracts of the plant. Also, a report has referred to the antitumor effects of this plant against esophageal cancer. ROS formation and lipid peroxidation were also concentration-dependently increased following treatment with U. dioica, similar to oxaliplatin. In addition, the number of apoptotic cells significantly increased concomitantly with concentration of U. dioica as compared with control cells, which is similar to oxaliplatin and serum-deprived cancer cells. U. dioica also inhibits proliferation of gastric and colorectal cancer cells while posing no significant toxic effect on normal cells. Clinical Study:https://www.ncbi.nlm.nih.gov/pubmed/30151067
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Werone.co endeavors to use the most potent source materials within our formulas. Our herbal extracts are sourced and tested by the only Government-certified large scale producer of crude herb (powder-free) TCM concentrates in Asia who manufacture to GMP / ISO 9001/2000 pharmaceutical grade and also operate an ISO17025/TAF-certified laboratory where they subject all plant extracts to strict quality inspections free from heavy metals, pesticides or microbes before release to the clinics all over the world. The formulas and tinctures are assembled without fillers in small batches by a BHMA member herbal dispensary.
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